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SAB1410774

Sigma-Aldrich

Anti-MAOA antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 59.7 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

NM_000240.2

UniProt accession no.

P21397

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAOA(4128)

General description

Monoamine oxidase A (MAOA) is encoded by the gene mapped to human chromosome Xp21-p11.The encoded protein is an isoform of MAO enzyme.

Immunogen

MAOA (NP_000231.1, 1 a.a. ~ 527 a.a) full-length human protein.

Sequence
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS

Biochem/physiol Actions

Monoamine oxidase A (MAOA) catalyzes the degradation of biogenic amines such as dopamine, noradrenaline and serotonin. Over activation of MAOA is associated with the human heart failure (HF) pathogenesis. Thus, the protein is considered to be a potential target for the treatment of HF.{32 }Mutation in the gene leads to panic disorder (PD).

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Monoamine Oxidase Is Overactivated in Left and Right Ventricles from Ischemic Hearts: An Intriguing Therapeutic Target.
Manni ME
Oxidative Medicine and Cellular Longevity (2016)
Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment.
Haberstick BC
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 135B, 59-64 (2005)
Human monoamine oxidase gene (MAOA): chromosome position (Xp21-p11) and DNA polymorphism.
Ozelius L
Genomics, 3, 53-58 (1988)
MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy.
Reif A
Molecular Psychiatry, 19, 122-128 (2014)

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