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SAB1411646

Sigma-Aldrich

Anti-CER1 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

Synonym(s):

DAND4, MGC119894, MGC119895, MGC96951

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 30.1 kDa

species reactivity

human, mouse

technique(s)

western blot: 1 μg/mL

NCBI accession no.

BC069491

UniProt accession no.

O95813

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CER1(9350)

General description

This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. (provided by RefSeq)

Immunogen

CER1 (AAH69491.1, 1 a.a. ~ 267 a.a) full-length human protein.

Sequence
MHLLLFQLLVLLPLGKTTRHQDGRQNQSSLSPVLLPRNQRELPTGNHEEAEEKPDLFVAVPHLVGTSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKVVVQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA

Biochem/physiol Actions

Cerberus 1 (CER1) is associated with the regulation of various pathways including nodal, Wnt, or BMP signaling pathways. During bone development, it acts as an inhibitor of BMPs (bone morphogenetic proteins). Polymorphisms in CER1 has link with osteoporosis, on bone mineral density (BMD) and bone markers in osteoporotic women. It has been reported that CER1 has been identified as a potential marker for bone mineral density and bone markers in osteoporotic women.

Physical form

Solution in phosphate buffered saline, pH 7.4

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wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Theodora Koromila et al.
Human genomics, 7, 21-21 (2013-10-22)
Osteoporosis has a multifactorial pathogenesis characterized by a combination of low bone mass and increased fragility. In our study, we focused on the effects of polymorphisms in CER1 and DKK1 genes, recently reported as important susceptibility genes for osteoporosis, on

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