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SAB2500042

Sigma-Aldrich

Anti-AIF1/IBA1 (Isoform 3) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-AIF-1, Anti-Allograft inflammatory factor 1, Anti-DASS-82G15.2, Anti-IBA1, Anti-IRT-1

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About This Item

MDL number:
MFCD02685938
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, rat, human

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P55008

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... AIF1(199)

Related Categories

General description

AIF1 (allograft inflammatory factor 1) is a calcium-binding, cytoplasmic protein that has 143-amino acids. It is also known as IBA1 (ionized calcium-binding adapter molecule 1). It is expressed in the cells of the monocyte/macrophage lineage, as well as in microglial and dendritic cells. It is located on human chromosome 6p21.3.

Immunogen

Peptide with sequence C-NKQFLDDPKYSSDED from the internal region of the protein sequence according to NP_001614.3.

Application

Anti-AIF1/IBA1 (Isoform 3) antibody produced in goat has been used in western blotting and immunofluorescence.

Biochem/physiol Actions

AIF1 (allograft inflammatory factor 1) is an essential factor of macrophage chemotaxis. Expression of AIF1 regulates the proliferation of vascular smooth muscle cells by G-CSF (cytokine granulocyte-colony stimulating factor) autocrine expression.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Inhibition of AIF-1 expression by constitutive siRNA expression reduces
macrophage migration, proliferation, and signal transduction initiated by
atherogenic stimuli.
Ying T, et al.
American Journal of Physiology. Cell Physiology (2005)
dolescent binge alcohol exposure affects the brain function through mitochondrial impairment
Tapia-Rojas C, et al.
Molecular Neurobiology, 55, 4473-4491 (2018)
Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation.
Arnulf H K, et al.
Acta Neuropathologica Communications, 4(1), 46-46 (2016)
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Wang Q, et al.
Cancer Cell, 32(1), 42-56 (2017)
Juciano Gasparotto et al.
Brain, behavior, and immunity, 62, 124-136 (2017-01-16)
Systemic inflammation induces transient or permanent dysfunction in the brain by exposing it to soluble inflammatory mediators. The receptor for advanced glycation endproducts (RAGE) binds to distinct ligands mediating and increasing inflammatory processes. In this study we used an LPS-induced
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