Skip to Content
MilliporeSigma
All Photos(1)

Documents

SAB2500260

Sigma-Aldrich

Anti-Complement Factor H antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CFH, Anti-CFHL3, Anti-HF, Anti-HGNC:4883

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P08603

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CFH(3075)

General description

Complement factor H (CFH) codes for 20 complement-control protein modules (CCPs 1–20). It is expressed in the liver, mesangial cells, endothelial cells and fibroblasts. It is a membrane cofactor protein. The CFH gene is localized on human chromosome 1q31.3.

Immunogen

Peptide with sequence C-HLVPDRKKDQYK from the internal region of the protein sequence according to NP_000177.2.

Biochem/physiol Actions

Complement factor H (CFH) is a negative regulator of the alternative pathway. It suppresses spontaneous complement activation and its response on self surfaces. CFH possesses decay-accelerating activity and destabilizes the C3b amplification in the alternate complement pathway. It also has a role in C3b cleavage by its cofactor activity. The protein has been linked to various diseases like age-related macular degeneration, kidney disorder and C3 glomerulopathy. CFH might prevent complement activation in ischemic renal injury by binding to tubular epithelial cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.
Naj AC
Annals of Human Genetics (2013)
Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface-selective regulation of complement activation.
Kerr H
The Journal of Biological Chemistry (2017)
Properdin and factor H production by human dendritic cells modulates their T-cell stimulatory capacity and is regulated by IFN-?.
Dixon KO
European Journal of Immunology (2017)
Interaction of uromodulin and complement factor H enhances C3b inactivation.
Liu M
Journal of Cellular and Molecular Medicine (2016)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service