Anti-Smooth Muscle α-Actin antibody produced in goat

Actin, a highly conserved protein, is a major component of both the cytoskeletal and contractile structures in all cell types. It varies in amount related to the type of differentiation and to the functional state of cells and tissues. Actin can be found in two different forms of aggregation, the globular or the fibrillar state, and at least six distinct isoforms occur in vertebrates. The actins exhibit over 90% sequence homology, but each isoform has a unique NH2-terminal sequence. The isoforms are comprised of three α actins (skeletal, cardiac, smooth), one β actin (β-non-muscle) and two γ actins (γ smooth muscle and γ non-muscle). Difficulties have been encountered in producing polyclonal antibodies due to the highly conserved nature of actin.

Goat polyclonal anti-smooth muscle α-Actin antibody reacts with canine, human, mouse, and rat smooth muscle α-actins (ACTA2).

Peptide with sequence EEEDSTALVC from the N Terminus of the protein sequence according to NP_001604.1.

Goat polyclonal anti-smooth muscle α-Actin antibody is used to tag smooth muscle α-actin (ACTA2) for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of smooth muscle α-actin in smooth muscle structure and as a marker of myofibroblast formation.

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Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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