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SAB2501252

Sigma-Aldrich

Anti-CLEC4C antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-BDCA2, Anti-CD303, Anti-CLECSF11, Anti-CLECSF7, C-type lectin domain family 4, member C

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q8WTT0

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CLEC4C(170482)

General description

C-type lectin domain family 4 member C (CLEC4C) is also known as blood dendritic cell antigen 2. It is expressed on plasmacytoid dendritic cells. CLEC4C is a type II transmembrane protein belonging to the C-type lectin (CTLs) superfamily. The protein consists of an extracellular carbohydrate recognition domain (CRD), a transmembrane region and a short cytoplasmic domain. The gene encoding CLEC4C is localized on human chromosome 12.

Immunogen

Peptide with sequence QSWTKSQKNCSV, from the Internal region of the protein sequence according to NP_569708.1; NP_987099.1.

Biochem/physiol Actions

C-type lectin domain family 4 member C (CLEC4C) is involved in intracellular signal transduction through the transmembrane adaptor, FcεRγ. It inhibits the secretion of soluble TNF-related apoptosis-inducing ligand (TRAIL). CLEC4C may have a role in ligand internalization.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2.
Jegouzo SA
The Journal of Biological Chemistry, 290(27), 16759-16771 (2015)
Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides.
Riboldi E
The Journal of Biological Chemistry, 35329-35333 (2011)
BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction.
Dzionek A
The Journal of Experimental Medicine, 194(12), 1823-1834 (2001)
Amy H Lin et al.
Journal of virology, 88(17), 10066-10077 (2014-06-27)
We developed a Moloney mouse leukemia virus (MLV)-based retroviral replicating vector (RRV), Toca 511, which has displayed tumor specificity in resected brain tumor material and blood in clinical trials. Here, we investigated the interaction between Toca 511 and human host

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