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SAB2501441

Sigma-Aldrich

Anti-MYO5A antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-GS1, Anti-MYH12, Anti-MYO5, Anti-MYR12, Myosin VA (heavy chain 12, myoxin)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, pig, bovine, mouse, rat

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q9Y4I1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MYO5A(4644)

Related Categories

General description

Myosin VA gene is mapped to human chromosome 15q21.2. It is a two-headed actin-based processive motor protein. Myosin VA comprises two heavy chains. Each chain has N-terminal motor domain, a neck region with six light chains and a coiled-coil and globular domain comprising tail region.

Immunogen

Peptide with sequence ETKQLELDLN, from the internal region of the protein sequence according to NP_000250.3; NP_001135967.1

Biochem/physiol Actions

Myosin VA associates with the microtubule-based motors and mediates organelle transport. It associates with Ras-related protein Rab-10 and mediates the glucose transporter type 4 translocation to plasma membrane. Mutations in the myosin VA is implicated in hypopigmentation disorder, Griscelli syndrome (GS1) and Elejalde syndrome.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes
Chen Y, et al.
The Journal of cell biology, 198(4), 545-560 (2012)
Congenital Hypopigmentary Disorders with Multiorgan Impairment: A Case Report and an Overview on Gray Hair Syndromes
Gironi LC, et al.
Medicina, 55(3), 78-78 (2019)
Ming Zhang et al.
Oxidative medicine and cellular longevity, 2014, 294150-294150 (2014-05-03)
The disruption of physiologic vascular smooth muscle cell (VSMC) migration initiates atherosclerosis development. The biochemical mechanisms leading to dysfunctional VSMC motility remain unknown. Recently, cytokine BMP-2 has been implicated in various vascular physiologic and pathologic processes. However, whether BMP-2 has
Myosin-V stepping kinetics: a molecular model for processivity
Rief M, et al.
Proceedings of the National Academy of Sciences of the USA, 97(17), 9482-9486 (2000)
A D Mehta et al.
Nature, 400(6744), 590-593 (1999-08-17)
Class-V myosins, one of 15 known classes of actin-based molecular motors, have been implicated in several forms of organelle transport, perhaps working with microtubule-based motors such as kinesin. Such movements may require a motor with mechanochemical properties distinct from those

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