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SAB3500326

Sigma-Aldrich

Anti-PKR antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Interferon-inducible RNA-dependent protein kinase, Anti-Protein kinase RNA-activated

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About This Item

MDL number:
MFCD03455796
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

AAP57628

UniProt accession no.

P19525

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... EIF2AK2(5610)

General description

EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) is an intracellular protein that is also called as RNA-dependent protein kinase (PKR). It belongs to the eIF2α family of protein kinases. The protein contains two RNA binding domains and a kinase domain. The PKR gene is localized on human chromosome 2p22-p21.

Immunogen

PKR antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human PKR.

Application

Anti-PKR antibody produced in rabbit has been used in Western Blotting.

Biochem/physiol Actions

EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) plays a key role in antiviral responses promoted by interferons. It is involved in stress response and inflammation pathways. EIF2AK2 controls the development and multiplication of cells, nutrient signaling and metabolism. The protein also participates in several cell regulatory pathways like antiviral activity, growth suppression, transcriptional regulation and apoptosis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500326.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

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Polymorphism in the NLRP3 inflammasome-associated EIF2AK2 gene and inflammatory bowel disease
Geena Paramel Varghese
Molecular Medicine Reports (2015)
Salidroside exhibits anti-dengue virus activity by upregulating host innate immune factors
Navita Sharma
Archives of Virology (2016)
Regulation of PKR by RNA: Formation of active and inactive dimers
Bushra Husain
Biochemistry (2015)
Yimeng Gao et al.
Immunity, 52(6), 1007-1021 (2020-06-05)
N6-methyladenosine (m6A) is the most abundant RNA modification, but little is known about its role in mammalian hematopoietic development. Here, we show that conditional deletion of the m6A writer METTL3 in murine fetal liver resulted in hematopoietic failure and perinatal

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