SAB3501198
Anti-Anthrax Protective Antigen antibody produced in rabbit
affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
liquid
species reactivity
Bacillus anthracis
concentration
1 mg/mL
technique(s)
ELISA: suitable
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
General description
Anthrax Protective Antigen Antibody: Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.
Immunogen
Anthrax protective antigen antibody was raised against a synthetic peptide corresponding to 14 amino acids at the carboxy terminus of the Anthrax protective antigen protein.The immunogen is located within amino acids 600 - 650 of Anthrax Protective Antigen.
Application
Anthrax protective antigen antibody can be used for the detection of Anthrax protective antigen protein in ELISA. It will detect 10 ng of free peptide at 1 μg/mL.
Physical form
Supplied in PBS containing 0.02% sodium azide.
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