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SAB3501232

Sigma-Aldrich

Anti-gp120 antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

liquid

species reactivity

human immunodeficiency virus 1

concentration

1 mg/mL

technique(s)

western blot: suitable

isotype

IgG

UniProt accession no.

Q6BBS3

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human immunodeficiency virus 1 ... env(155971)

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General description

gp120 Antibody: Human immunodeficiency virus type 1 (HIV-1) entry into target cells is directed by the envelope (Env) glycoproteins, which are present on the surface of HIV-1 virion or infected cells in the form of trimers consisting of gp120/gp41 complexes. The surface subunit, gp120, initiates the entry process by interacting sequentially with the CD4 receptor and a co-receptor CCR5 or CXCR4, thereby inducing a conformational change that allows the transmembrane (TM) gp41 subunit to mediate fusion between viral and target cell membranes. Cleavage of Env into its gp120 and gp41 components is necessary for activation of its fusogenic activity.

Immunogen

gp120 antibody was raised against 16 amino acid synthetic peptide representing the major HIV-1 consensus sequence near the N-terminal region of V1/V2 loop.The immunogen is located within amino acids 80 - 130 of gp120.

Application

Gp120 antibody can be used for detection of gp120 by Western blot at 1 μg/mL.

Physical form

Supplied in PBS containing 0.02% sodium azide.

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