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SAB3701436

Sigma-Aldrich

Monoclonal Anti-Hsc70 (Hsp73) antibody produced in mouse

clone N27F3-4, purified immunoglobulin

Synonym(s):

Anti-HSC54 antibody, Anti-HSC71 antibody, Anti-Heat shock protein 8 antibody, Anti-Heat-shock70-KD protein 10, Anti-MHV-A59

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

N27F3-4, monoclonal

form

buffered aqueous solution

species reactivity

canine, bovine, salmon, beluga, rat, Caenorhabditis elegans, human, carp, Drosophila, mouse, chicken

technique(s)

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG1

UniProt accession no.

P0DMV8

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HSPA1A(3303)

Specificity

This Protein G purified monoclonal antibody reacts with human Hsc70 (Hsp73) protein.   A BLAST analysis was used to suggest cross-reactivity with Hsc70 from human, bovine, mouse, rat, C.elegans, beluga, dog, chicken, Drosophila, carp, salmon, trout, guinea pig, hamster, monkey, pig, cucumber, pea, rabbit, sheep and Xenopus sources based on 100% homology with the immunizing sequence.  This antibody recognizes both the inducible hsp and the constitutively expressed hsc as 72 kDa and 73 kDa proteins, respectively.  Cross-reactivity with Hsp70 from other sources has not been determined.

Immunogen

Synthetic peptide corresponding to a region of human Hsc70 (Hsp73) protein.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.1% (w/v) Sodium Azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

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Hashim Ali et al.
Nature communications, 10(1), 926-926 (2019-02-26)
Productive HIV-1 replication requires viral integrase (IN), which catalyzes integration of the viral genome into the host cell DNA. IN, however, is short lived and is rapidly degraded by the host ubiquitin-proteasome system. To identify the cellular factors responsible for

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