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SAB4200230

Sigma-Aldrich

Anti-DPP4/CD26 antibody, Mouse monoclonal

clone A6H, purified from hybridoma cell culture

Synonym(s):

Monoclonal Anti-ADABP, Monoclonal Anti-ADCP2, Monoclonal Anti-DPPIV, Monoclonal Anti-TP103, Monoclonal Anti-dipeptidyl-peptidase 4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

A6H, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

~4.0 mg/mL

technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
indirect immunofluorescence: 20-40 μg/mL using methanol/acetone fixed HT-29 cells

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DPP4(1803)

Related Categories

General description

Monoclonal Anti-DPP4/CD26 (mouse IgG1 isotype) is derived from the hybridoma A6H produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human fetal homogenates. Dipeptidyl peptidase-4 (DPP4) belongs to the S9B protein family, which cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides and peptide hormones. It is a type II transmembrane glycoprotein, expressed on the surface of many cell types.

Immunogen

human fetal homogenates.

Application

Monoclonal Anti-DPP4/CD26 antibody produced in mouse has been used in:
  • enzyme linked immuno sorbent assay (ELISA)
  • immunocytochemistry
  • immunohistochemistry
  • flow cytometry

Biochem/physiol Actions

Dipeptidyl peptidase-4 (DPP4) is involved in the regulation of the biological activity of hormones and chemokines, such as glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. DPP4 inhibition maybe used to treat type 2 diabetes mellitus. It acts as a T cell activation molecule and regulates immunity and immune-mediated disorders.

Physical form

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK 1

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Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Dipeptidyl peptidase-4 (CD26): knowing the function before inhibiting the enzyme
Matteucci E and Giampietro O
Current Medicinal Chemistry, 16(23), 2943-2951 (2009)
G M Hass et al.
Hybridoma, 20(4), 231-236 (2001-10-18)
The monoclonal antibody (MAb) A6H, originally developed to fetal renal tissues, was found to be highly reactive to renal cell carcinoma and was subsequently demonstrated to co-stimulate a subpopulation of T cells. The A6H antigen had not been identified heretofore.
R L Vessella et al.
Cancer research, 45(12 Pt 1), 6131-6139 (1985-12-01)
Monoclonal antibodies (MABs) reactive with human renal cell carcinoma (RCC) were generated following immunization of mice with either RCC homogenates, RCC cell lines, or fetal kidney homogenates. The characteristics of four highly reactive immunoglobulin G1 MABs, designated UMVA-RCC-A6H, UMVA-RCC-A36, UMVA-RCC-C5H

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