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SAB4200566

Anti-KHSRP antibody produced in rabbit

Name: Anti-KHSRP antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody

Synonym(s):

Anti-FBP2, Anti-FUBP2, Anti-KH-type splicing regulatory protein, Anti-KSRP, Anti-MGC99676

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~82 kDa

species reactivity

rat, mouse, human

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 1-2 μg using lysates of human HEK-293T cells
western blot: 0.25-0.50 μg/mL using whole extracts of mouse NIH-3T3 cells

UniProt accession no.

Q92945

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KHSRP(8570)
mouse ... Khsrp(16549)
rat ... Khsrp(171137)

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Primary Antibodies

General description

K-homology type-splicing regulatory protein (KHSRP) is a multifunctional RNA-binding protein. It contains four K homology RNA-binding domains and an unusual C-terminal domain. KHSRP is localized in neural and non-neural cell lines. It is located on the human chromosome at 19p13.3.

Specificity

Anti-KHSRP recognizes human, mouse and rat KHSRP.

Immunogen

synthetic peptide corresponding to an internal region of human KHSRP (GeneID: 8570), conjugated to KLH. The corresponding sequence is identical in rat, mouse, monkey, pig and dog KHSPR.

Application

Anti-KHSRP antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

Biochem/physiol Actions

K-homology type-splicing regulatory protein (KHSRP) is involved in several cellular processes such as transcription, mRNA localization and alternative pre-mRNA splicing. It is also involved in mRNA decay and microRNA precursor maturation.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease.

Paola Briata et al.

Wiley interdisciplinary reviews. RNA, 7(2), 227-240 (2015-12-29)

The single-stranded nucleic acid-binding protein KHSRP (KH-type splicing regulatory protein) modulates RNA life and gene expression at various levels. KHSRP controls important cellular functions as different as proliferation, differentiation, metabolism, and response to infectious agents. We summarize and discuss experimental

Mapping of theKHSRPGene to a Region of Conserved Synteny on Human Chromosome 19p13. 3 and Mouse Chromosome 17

Ring H Z, et al.

Genomics, 56(3), 350-352 (1999)

A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer.

H Min et al.

Genes & development, 11(8), 1023-1036 (1997-04-15)

We have purified and cloned a new splicing factor, KSRP. KSRP is a component of a multiprotein complex that binds specifically to an intronic splicing enhancer element downstream of the neuron-specific c-src N1 exon. This 75-kD protein induces the assembly

A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3'UTR-Mediated Protein-Protein Interactions

Ma W and Mayr C

Cell, 175(6), 1492-1506 (2018)

A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3'UTR-Mediated Protein-Protein Interactions.

Weirui Ma et al.

Cell, 175(6), 1492-1506 (2018-11-20)

Approximately half of human genes generate mRNAs with alternative 3' untranslated regions (3'UTRs). Through 3'UTR-mediated protein-protein interactions, alternative 3'UTRs enable multi-functionality of proteins with identical amino acid sequence. While studying how information on protein features is transferred from 3'UTRs to

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