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SAB4300461

Sigma-Aldrich

Anti-RAC1 (Ab-71) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-MGC111543 antibody produced in rabbit, Anti-MIG5 antibody produced in rabbit, Anti-TC-25 antibody produced in rabbit, Anti-p21-Rac1 antibody produced in rabbit, Anti-ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) antibody produced in rabbit

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About This Item

MDL number:
MFCD01322704
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~28 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(P-L-S-Y-P)

NCBI accession no.

NP_008839.2

UniProt accession no.

P63000

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RAC1(5879)

General description

RAC1 (ras-related C3 botulinum toxin substrate 1) is a polarity related protein , that belongs to the Rho family of small guanosine triphosphatases. It is located on human chromosome 7p22.

Immunogen

Peptide sequence around aa. 69-73 (P-L-S-Y-P), according to the protein RAC1.

Application

Anti-RAC1 (Ab-71) antibody has been used in western blot analysis .

Biochem/physiol Actions

RAC1 (ras-related C3 botulinum toxin substrate 1) plays a major role in cancer invasion and metastasis. It can be considered as a therapeutic target for breast cancer. It is essential for several cellular activities like phagocytosis, adhesion, migration, motility, cell proliferation and axonal growth.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Rac1 encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Case of 7p22.1 Microduplication Detected by Whole Genome Microarray (REVEAL) in Workup of Child Diagnosed with Autism
Goitia V, et al.
Case Reports in Genetics (2015)
Emerging roles of RAC1 in treating lung cancer patients
Zou T, et al.
Clinical Genetics, 91(4), 520-528 (2017)
Estradiol attenuates the TGF-?1-induced conversion of primary TAFs into myofibroblasts and inhibits collagen production and myofibroblast contraction by modulating the Smad and Rho/ROCK signaling pathways
Jiang HS, et al.
International Journal of Molecular Medicine, 36(3), 801-807 (2015)
High expression of Rac1 is correlated with partial reversed cell polarity and poor prognosis in invasive ductal carcinoma of the breast
Liu B, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(7) (2017)
Caixia Yuan et al.
Experimental and therapeutic medicine, 17(4), 2547-2556 (2019-03-25)
Bone morphogenetic protein (BMP) expression has been observed in the uterus in previous studies. However, the influence of BMP7 on blastocyst implantation remains unclear. Blastocysts first act on luminal endometrial epithelial cells during implantation. The purpose of the present study
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