SAB4300488
Anti-FGFR1 (Ab-154) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-BFGFR antibody produced in rabbit, Anti-CD331 antibody produced in rabbit, Anti-CEK antibody produced in rabbit, Anti-FGFBR antibody produced in rabbit, Anti-fibroblast growth factor receptor 1 antibody produced in rabbit
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~145 kDa
species reactivity
human, mouse
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(A-P-Y-W-T)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FGFR1(2260)
Related Categories
General description
FGFR1 (fibroblast growth factor receptor 1) gene codes for 9 isoforms of FGFR1. It has 19 exons spanning 55kb DNA. It is located on human chromosome 8p11.1. High level expression of FGFR1 is seen in midfacial membranous ossification sites. It is mostly present in neurons like hippocampal and dentate gyrus neurons.
Immunogen
Peptide sequence around aa. 152-156 (A-P-Y-W-T), according to the protein FGFR1.
Application
Anti-FGFR1 (Ab-154) antibody has been used in western blotting .
Biochem/physiol Actions
FGFR1 (fibroblast growth factor receptor 1) helps in the growth of nervous system. It also controls the skeletal development and bone homeostasis. FGFR1 mutations lead to craniosynostosis and facial abnormalities. Mutation in FGFR1 Ig-like domain II-III linker region (FGFR1 P252R) results in Pfeiffer syndrome.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Target description
FGF encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Product No.
Description
Pricing
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Contribution of FGFR1 Variants to Craniofacial Variations in East Asians
Adel M, et al.
PLoS ONE, 12(1) (2017)
BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR
Makani V, et al.
PLoS ONE, 11(3) (2016)
Vishruti Makani et al.
PloS one, 11(3), e0149715-e0149715 (2016-03-05)
An enormous amount of efforts have been poured to find an effective therapeutic agent for the treatment of neurodegenerative diseases including Alzheimer's disease (AD). Among those, neurotrophic peptides that regenerate neuronal structures and increase neuron survival show a promise in
Xu Guan et al.
The Journal of pathology, 234(4), 560-572 (2014-08-19)
Increased basic fibroblast growth factor-2 (FGF2) and reduced Klotho have both been reported to be closely associated with renal fibrosis. However, the relationship between Klotho and FGF2 remains unclear. We demonstrate that FGF2 induced tubulo-epithelial plasticity in cultured HK-2 cells
B Nadratowska-Wesolowska et al.
Oncogene, 33(40), 4823-4836 (2013-10-22)
FGFR1 (fibroblast growth factor receptor 1) regulates many key cellular responses including proliferation, migration and differentiation through activation of signaling pathways. Irregularities in FGFR1 signaling have been implicated in several pathological conditions, including human cancer. In order to discover novel
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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