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SAB4300492

Sigma-Aldrich

Anti-CDC2 (Ab-15) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CDC28A antibody produced in rabbit, Anti-CDK1 antibody produced in rabbit, Anti-DKFZp686L20222 antibody produced in rabbit, Anti-MGC111195 antibody produced in rabbit, Anti-cell division cycle 2, G1 to S and G2 to M antibody produced in rabbit

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About This Item

MDL number:
MFCD00239719
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~34 kDa

species reactivity

human, rat, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(G-T-Y-G-V)

NCBI accession no.

NP_001163877.1

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CDC2(983)

General description

CDC2/CDK1 (cyclin-dependent kinase 1) belongs to the Ser/Thr protein kinase family. It is located on human chromosome 10q21.

Immunogen

Peptide sequence around aa. 13-17 (G-T-Y-G-V), according to the protein CDC2.

Biochem/physiol Actions

CDC2/CDK1 (cyclin-dependent kinase 1) controls various mitotic processes like reorganization of the cytoskeleton, segregation of chromosome, formation and separation of daughter cells. It is essential for the multiplication of mammalian cell. It participates in tumorigenesis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy
Bieche I, et al.
Molecular Cancer, 10:23 (2011)
Recurrent CDK1 overexpression in laryngeal squamous cell carcinoma
Bednarek K, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(8), 11115-11126 (2016)
Identification of Candidate Cyclin-dependent kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics
Petrone A, et al.
Molecular and Cellular Proteomics, 15(7), 2448-2461 (2016)

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