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SAB4300637

Sigma-Aldrich

Anti-FGFR4 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CD334, Anti-JTK2, Anti-MGC20292, Anti-TKF

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~110 kDa

species reactivity

human, rat

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(L-T-V-A-L)

NCBI accession no.

NM_002011.3

UniProt accession no.

P22455

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FGFR4(2264)

General description

FGFR4 (fibroblast growth factor receptor 4) belongs to FGFR kinase family. In adult tissues, FGFR is expressed in a cell type-specific mode. It is located on chromosome 5q35.

The antibody detects endogenous level of total FGFR4 protein.

Immunogen

Peptide sequence around aa. 45-49 ( L-T-V-A-L), according to the protein NP_002002.3

Biochem/physiol Actions

Aberrations in FGFR4 results in neuroblastoma and altered receptor degradation. It acts as a predictive biomarker in oral and oropharyngeal squamous cell carcinoma. Suppressing FGFR4 may affect the biological characteristics in gastric cancer cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The role of genetic and epigenetic changes in pituitary tumorigenesis
Fukuoka H and Takahashi Y
Neurologia Medico-Chirurgica (2014)
A Polymorphism in the FGFR4 Gene Is Associated With Risk of Neuroblastoma and Altered Receptor Degradation
Whittle SB, et al.
Journal of Pediatric Hematology (2016)
FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma
Koole K, et al.
Pathobiology (2015)
Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
Yu C, et al.
The Journal of Biological Chemistry (2000)
Silencing of FGFR4 could influence the biological features of gastric cancer cells and its therapeutic value in gastric cancer
Ye Y, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine (2016)
View All Related Papers

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