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SAB4300706

Sigma-Aldrich

Anti-Ring1A antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-RING1, Anti-RNF1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~58 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(I-A-V-S-P)

NCBI accession no.

NM_002931.3

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... Ring1A(6015)

General description

The antibody detects endogenous level of total Ring1A protein.

Immunogen

Peptide sequence around aa. 35-39 ( I-A-V-S-P), according to the protein NP_002922.2

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of ′Lys-119′ of histone H2A, thereby playing a central role in histone code and gene regulation. H2A ′Lys-119′ ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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