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SAB4500475

Sigma-Aldrich

Anti-NEK7 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

NEK7, NimA-related protein kinase 7, Serine/threonine-protein kinase Nek7

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 34 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

Q8TDX7

UniProt accession no.

Q8TDX7

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NEK7(140609)

General description

NIMA-related Kinase 7/never in mitosis A-related kinase 7 (NEK7), a serine/threonine kinase belongs to the NIMA-related protein kinase (NEK) family. It is the smallest NIMA-related kinase (NEK) protein seen in mammals, which is made up of a catalytic domain with a 30–40 amino acid N-terminal extension. NEK7 is abundantly expressed in the heart, liver, testis, lung, muscle, brain, spleen, and leukocyte. The NEK7 gene is located on human chromosome 1.

Immunogen

The antiserum was produced against synthesized peptide derived from human NEK7.

Immunogen Range: 101-150

Biochem/physiol Actions

NIMA-related Kinase 7/never in mitosis A-related kinase 7 (NEK7) is essential to form procentriole. It participates in regulating the cell cycle. In addition to the pathological and physiological effects, NEK7 is also involved in the formation of the spindle during mitosis. It is expressed at a high level in gallbladder cancer. NEK7 controls cytokinesis and stability of the microtubule. It can activate the spindle assembly checkpoint. NEK7 might also be associated with hepatocellular carcinoma (HCC).

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Certificates of Analysis (COA)

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Zhenzhen Sun et al.
Frontiers in physiology, 11, 606996-606996 (2020-12-29)
NEK7 is the smallest NIMA-related kinase (NEK) in mammals. The pathological and physiological roles of NEK7 have been widely reported in many studies. To date, the major function of NEK7 has been well documented in mitosis and NLRP3 inflammasome activation
Akshari Gupta et al.
Molecular biology of the cell, 28(15), 2123-2134 (2017-05-26)
The decision to commit to the cell cycle is made during G1 through the concerted action of various cyclin-CDK complexes. Not only DNA replication, but also centriole duplication is initiated as cells enter the S-phase. The NIMA-related kinase NEK7 is

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