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SAB4500493

Sigma-Aldrich

Anti-p38 MAPK antibody produced in rabbit

affinity isolated antibody

Synonym(s):

MAP kinase MXI2, MAP kinase p38, MAPK14, kinase p38-α

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About This Item

MDL number:
MFCD00803556
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 41 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI accession no.

Q16539

UniProt accession no.

Q16539

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAPK14(1432)

General description

Anti-p38 MAPK Antibody detects endogenous levels of total p38 MAPK protein.
p38 mitogen-activated protein kinase (MAPK), also known as, mitogen-activated protein kinase 14 (MAPK14)/ p38α, is encoded by the gene mapped on human chromosome 6p21.31. The encoded protein is a Ser/Thr kinase composed of 90 to 360 residues. p38α MAPK is ubiquitously expressed. It is found in the cytosol, but it can translocate to the nucleus.

Immunogen

The antiserum was produced against synthesized peptide derived from human p38 MAPK.

Immunogen Range: 147-196

Application

Anti-p38 MAPK antibody produced in rabbit has been used in western blot analysis.

Biochem/physiol Actions

p38 mitogen-activated protein kinase (MAPK)/MAPK14 (mitogen-activated protein kinase 14) participates in resistance of colon cancer cells to camptothecin-related drugs. This protein is required for the growth of embryos. This gene controls proliferation, differentiation, cell death, adhesion, migration, as well as the response to stress and many metabolic pathways. Genetic variation in p38α leads to deletion or overproduction of myelosuppressive cytokines and result in certain bone marrow failure syndromes.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Inflammation, 38(4), 1617-1623 (2015)
Resveratrol-induced autophagy promotes survival and attenuates doxorubicin-induced cardiotoxicity
Gu J, et al.
International Immunopharmacology, 32, 1-7 (2016)
MAPK14 (mitogen-activated protein kinase 14)
Porras A, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2011)
MAPK14/p38? confers irinotecan resistance to TP53-defective cells by inducing survival autophagy.
Paillas S, et al.
Autophagy, 8(7), 1098-1112 (2012)
Jin-Hao Miao et al.
Oncology reports, 32(4), 1497-1504 (2014-07-30)
Galectin-1 (GAL1), a widely expressed β‑galacto-side-binding protein, exerts pleiotropic biological functions. GAL1 has been found to be upregulated in many malignancies; yet the role of GAL1 in the pathophysiology of human osteosarcoma (OS) remains uncertain. The present study was carried
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