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SAB4500577

Sigma-Aldrich

Anti-ADRB2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ADRBR, B2AR, BAR, BETA2AR, β-2 adrenergic receptor, β-2 adrenoceptor, β-2 adrenoreceptor, ADRB2, ADRB2R

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 46 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

P07550

UniProt accession no.

P07550

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADRB2(154)

General description

Anti-ADRB2 Antibody detects endogenous levels of total ADRB2 protein.
Adrenoceptor β 2/β2 adrenergic receptor (ADRB2), a transmembrane protein, belongs to the superfamily of G-protein coupled receptors (GPCRs). This protein is expressed in skeletal muscle, mast cells, lymphocytes, airway smooth muscle, epithelial and endothelial cells of the lung, the smooth muscle of blood vessels, oral and skin keratinocytes. It comprises seven transmembrane domains and three extracellular and three intracellular loops. ADRB2 gene is located on human chromosome 5q32. Anti-ADRB2 Antibody detects endogenous levels of total ADRB2 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human ADRB2.

Immunogen Range: 201-250

Biochem/physiol Actions

Adrenoceptor β 2/β2 adrenergic receptor (ADRB2) binding to agonist activates Gs protein. Variation in the ADRB2 gene is involved in blood pressure (BP) and body mass index (BMI). ADRB2 is associated with nasopharyngeal carcinoma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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ADRB2 (adrenoceptor beta 2, surface)
Oliveira DT and Calderon DMB
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2021)
Roderic J Phillips et al.
Journal of paediatrics and child health, 50(8), 619-625 (2014-06-07)
To describe the clinical and histopathological characteristics of infantile haemangiomas that failed treatment with oral propranolol . This study is a case series from the vascular birthmarks clinic at Royal Children's Hospital, Melbourne. The patients for this study were infants

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