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SAB4501126

Sigma-Aldrich

Anti-GATA3 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

GATA-binding factor 3, Trans-acting T-cell specific transcription factor GATA-3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 47 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

NCBI accession no.

P23771

UniProt accession no.

P23771

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GATA3(2625)

Related Categories

General description

Anti-GATA3 antibody detects endogenous levels of total GATA3 protein.
GATA-3 (GATA binding protein 3) is a T-cell transcription factor. It is highly expressed in fetal and adult thymus. It is located on human chromosome 10p14.

Immunogen

The antiserum was produced against synthesized peptide derived from human GATA3.

Immunogen Range: 274-323

Biochem/physiol Actions

GATA-3 (GATA binding protein 3) plays an important role in the growth of T-cell neoplasms and early growth of T-cells. It acts as a specific marker in breast and urothelial carcinomas. GATA3 also acts as an immunophenotypic marker of acute leukemias.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

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T-cell transcription factor GATA-3 is an immunophenotypic marker of acute leukemias with T-cell differentiation
Dorfman DM, et al.
Human Pathology, 65, 166-174 (2017)
Characterisation of GATA3 expression in invasive breast cancer: differences in histological subtypes and immunohistochemically defined molecular subtypes
Shaoxian T, et al.
Journal of Clinical Pathology (2017)
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)
Enciso-Mora V, et al.
Nature Genetics (2010)
Nazneen Fatima et al.
Human pathology, 45(8), 1625-1629 (2014-05-16)
The current available data on GATA-binding protein 3 (GATA3) expression in sarcomatoid urothelial carcinoma are limited, especially in the non-tissue microarray-based setting. In this study, we analyzed the expression of GATA3 in sarcomatoid urothelial carcinoma of the bladder in cystectomy/cystoprostatectomy

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