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SAB4501277

Sigma-Aldrich

Anti-GPR35 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

GPR35, Probable G-protein coupled receptor 35

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 34 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

Q9HC97

UniProt accession no.

Q9HC97

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GPR35(2859)

Related Categories

General description

Anti-GPR35 Antibody detects endogenous levels of total GPR35 protein.

GPR35 (G protein-coupled receptor 35) is a lysophosphatidic acid receptor. It is highly expressed in the immune and gastrointestinal systems, dorsal root ganglia, cerebellum and brain. It is mapped to human chromosome 2q37.3 .

Immunogen

The antiserum was produced against synthesized peptide derived from human GPR35.

Immunogen Range: 51-100

Biochem/physiol Actions

GPR35 (G protein-coupled receptor 35) is involved in heart failure and pain perception. It also participates in the formation of gastric cancer. It serves as a receptor for the kynurenine pathway intermediate kynurenic acid. It can also acts as an important lysophosphatidic acid receptor.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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GPR35 is a novel lysophosphatidic acid receptor
Oka S, et al.
Biochemical and Biophysical Research Communications, 395(2), 232-237 (2010)
Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells
Okumura S, et al.
Cancer Science, 95(2), 131-135 (2004)
GPR35 as a Novel Therapeutic Target
Mackenzie AE, et al.
Frontiers in Endocrinology, 2 (2011)
Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35
Wang J, et al.
The Journal of Biological Chemistry, 281(31), 22021-22028 (2006)
Crucial positively charged residues for ligand activation of the GPR35 receptor
Zhao P, et al.
The Journal of Biological Chemistry, 289(6), 3625-3638 (2014)
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