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SAB4501285

Sigma-Aldrich

Anti-TRIM59 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

RING finger protein 104, Tumor suppressor TSBF-1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 47 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

Q8IWR1

UniProt accession no.

Q8IWR1

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TRIM59(286827)

Related Categories

General description

Anti-TRIM59 Antibody detects endogenous levels of total TRIM59 protein.
TRIM59 (tripartite-59) belongs to the tripartite motif (TRIM) family of proteins. It has a RING domain, one or two B-box motifs and a coiled-coil region. It is located on human chromosome 3q25.

Immunogen

The antiserum was produced against synthesized peptide derived from human TRIM59.

Immunogen Range: 191-240

Biochem/physiol Actions

Suppression of tripartite-59 (TRIM59) blocks the multiplication and migration of cervical cancer cells. In prostate cancer models, TRIM59 serves as a proto-oncogene that affects Ras and RB signal pathways. It also induces the multiplication and migration of non-small cell lung cancer cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Donor age and C1orf132/MIR29B2C determine age-related methylation signature of blood after allogeneic hematopoietic stem cell transplantation
Spolnicka M, et al.
Clinical epigenetics (2016)
Knockdown of Tripartite-59 (TRIM59) Inhibits Cellular Proliferation and Migration in Human Cervical Cancer Cells
Aierken G, et al.
Oncology Research, 25, 381-388 (2017)
TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins
Zhan W, et al.
PLoS ONE, 10 (2015)

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