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SAB4501408

Sigma-Aldrich

Anti-HNF4 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

HNF-4, HNF-4-α, HNF4, HNF4A, Hepatocyte nuclear factor 4-α

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 52 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI accession no.

P41235

UniProt accession no.

P41235

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HNF4A(3172)

General description

Anti-HNF4 Antibody detects endogenous levels of total HNF4 protein.
Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor, located on human chromosome 20q13.12.

Immunogen

The antiserum was produced against synthesized peptide derived from human HNF4 alpha.

Immunogen Range: 280-329

Biochem/physiol Actions

Hepatocyte nuclear factor 4 alpha (HNF4α) plays an important role in the growth of liver. Mutations in HNF4α results in maturity onset diabetes of the young (MODY).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4α.
Hu X, et al.
Biochemical and Biophysical Research Communications, 478(2), 791-797 (2016)
Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population.
Lin WH, et al.
Diabetologia, 49(6), 1214-1221 (2006)
The Common p.R114W HNF4A Mutation Causes a Distinct Clinical Subtype of Monogenic Diabetes.
Laver TW, et al.
Diabetes, 65(10), 3212-3217 (2016)
Katharina Prestin et al.
American journal of physiology. Renal physiology, 307(9), F1041-F1051 (2014-09-12)
Renal tubular handling of urate is realized by a network of uptake and efflux transporters, including members of drug transporter families such as solute carrier proteins and ATP-binding cassette transporters. Solute carrier family 2, member 9 (SLC2A9), is one key

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