SAB4501720
Anti-LAMA5 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
α 5, laminin, laminin α 5, laminin α-5
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 399 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... LAMA5(3911)
Related Categories
General description
Anti-LAMA5 Antibody detects endogenous levels of total LAMA5 protein. Laminin alpha5 (LAMA5) codes for the laminin α5 chain. It is mapped to human chromosome 20q13.2- q13.3. In human skin, LAMA5 is produced and liberated by dermal pericytes.
Immunogen
The antiserum was produced against synthesized peptide derived from human LAMA5.
Immunogen Range: 2381-2430
Immunogen Range: 2381-2430
Application
Anti-LAMA5 antibody has been used in immunohistochemistry, immunocytochemistry and immunofluorescent staining.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
Biochem/physiol Actions
Furthermore, studies in mice showed that Lama5 is involved in organogenesis and placental function during pregnancy. LAMA5 may play a role in regulating inter-individual variability in metabolic phenotypes in children. It induces skin regeneration both in vitro and in vivo.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Common variants in the LAMA5 gene associate with fasting plasma glucose and serum triglyceride levels in a cohort of pre-and early pubertal children.
De Luca M, et al.
Journal of pediatric genetics, 1(4), 229-234 (2012)
A role for pericytes as microenvironmental regulators of human skin tissue regeneration.
Paquet-Fifield S, et al.
The Journal of Clinical Investigation, 119(9), 2795-2806 (2009)
Glícia Maria de Almeida et al.
Scientific reports, 5, 17860-17860 (2015-12-15)
Extracellular matrix (ECM) is known to play several important roles in vascular development, although the molecular mechanisms behind these remain largely unknown. RECK, a tumor suppressor downregulated in a wide variety of cancers, encodes a membrane-anchored matrix-metalloproteinase-regulator. Mice lacking functional
Jyoti Gautam et al.
Scientific reports, 6, 36450-36450 (2016-11-04)
Laminin, a major component of the basement membrane, plays an important role in blood brain barrier regulation. At the neurovascular unit, brain endothelial cells, astrocytes, and pericytes synthesize and deposit different laminin isoforms into the basement membrane. It has been
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