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SAB4502609

Sigma-Aldrich

Anti-NF-κB p65 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

NFKB3, RELA, TF65, nuclear factor NF-κ-B p65 subunit, p65

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About This Item

MDL number:
MFCD00802848
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 60 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
western blot: 1:500-1:1000

NCBI accession no.

Q04206

UniProt accession no.

Q04206

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RELA(5970)

General description

Anti-NF-κB p65 antibody detects endogenous levels of total NF-κB p65 protein.
The NF-κB p65 (nuclear factor κ-light-chain-enhancer of activated B cells p65) gene is mapped to human chromosome 11q13.1. It codes for a transcription factor, a subunit of NF-κB.

Immunogen

The antiserum was produced against synthesized peptide derived from human NF-kappaB p65.

Immunogen Range: 278-327

Application

Anti-NF-κB p65 antibody produced in rabbit has been used in western blot analysis.

Biochem/physiol Actions

NF-κB p65 (nuclear factor κ-light-chain-enhancer of activated B cells p65) is associated with many fibrotic diseases such as liver fibrosis and cardiac fibrosis. Cell proliferation, inflammation, and apoptosis are some of the processes mediated by NF-κB p65. Dysregulation of the gene results in chronic inflammatory diseases, autoimmune disorders and cancer. NF-κB p65 plays an important role in NF-κB signaling.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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RelA/p65 inhibition prevents tendon adhesion by modulating inflammation, cell proliferation, and apoptosis.
Chen S
Cell Death & Disease, 8(3), 1-13 (2017)
The role of hyperuricemia on vascular endothelium dysfunction.
Zhen H and Gui F
Biomedical Reports, 7(4), 325-330 (2017)
Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNF? stimulation regulates DNA binding and transcription.
Lanucara F
Open Biology, 6(7)., 1-14 (2016)
Danshensu protects against ischemia/reperfusion injury and inhibits the apoptosis of H9c2 cells by reducing the calcium overload through the p-JNK-NF-?B-TRPC6 pathway.
Meng Y
International Journal of Molecular Medicine, 37(1), 258-266 (2016)
C11orf95-RELA fusions drive oncogenic NF-?B signalling in ependymoma.
Parker M
Nature, 506(7489), 451-455 (2014)
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