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SAB4502631

Sigma-Aldrich

Anti-Actin-pan antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ACTA, ACTA1, ACTS, Actin α skeletal muscle

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 41 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P68032

UniProt accession no.

P68032

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ACTA1(58)

General description

Anti-Actin-pan antibody detects endogenous levels of total actin-pan protein.
The ACTA1 (actin, α1) gene is mapped to human chromosome 1q42.13. The gene codes for actin 1, a thin filament component of skeletal muscle.

Immunogen

The antiserum was produced against synthesized peptide derived from human Actin.

Immunogen Range: 21-70

Biochem/physiol Actions

Mutations in ACTA1 (actin, α1) is known to cause thin filament myopathy, such as nemaline myopathy, congenital myopathy, actin myopathy, intranuclear rod myopathy, cap myopathy and core myopathy. Upregulation of the gene is observed in orthotopic liver transplantation without any earlier evidence of autoimmune liver disease. The encoded protein actin forms a network of filaments and is responsible for the shape of the cell. It provides cellular strength and promotes active movement of the cell.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments.
Hansen SD and Mullins RD
eLife, 4, 1-29 (2015)
Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases.
Pellegrini L
BioMed Research International, 2017, 1-7 (2017)
Severe congenital actin related myopathy with myofibrillar myopathy features.
Selcen D
Neuromuscular Disorders, 25(6), 488-492 (2015)
Mutation-specific effects on thin filament length in thin filament myopathy.
Winter JM
Annals of Neurology, 79(6), 959-969 (2016)
A Mutation in the ACTA1 gene Manifesting Nemaline Myopathy with Central Nervous System Lesions.
Ueda K
Journal of clinical neurology (Seoul, Korea), 13(3), 300-302 (2017)
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