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SAB4502896

Sigma-Aldrich

Anti-CD147, C-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym(s):

BASI, CD147, basigin, basigin (Ok blood group), collagenase stimulatory factor

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About This Item

MDL number:
MFCD02262857
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 42 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P35613

UniProt accession no.

P35613

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BSG(682)

Related Categories

General description

Anti-CD147 Antibody detects endogenous levels of total CD147 protein.
Cluster of differentiation 147 (CD147) is a multifunctional trans-membrane glycoprotein and is a member of the immunoglobulin superfamily. It occurs in transmembrane and soluble forms. CD147 is also known as EMMPRIN or basigin (BSG). It is a 57 kDa glycoprotein with two extracellular Ig domains. CD147 is located on human chromosome 19p13.

Immunogen

The antiserum was produced against synthesized peptide derived from human CD147.

Immunogen Range: 336-385

Application

Anti-CD147, C-Terminal antibody has been used in western blotting.

Biochem/physiol Actions

Cluster of differentiation 147 (CD147) is considered as an extracellular matrix metalloproteinase inducer. It participates in several physiological and pathological activities, mainly in tumor invasion and metastasis. CD147 helps in tumor cell-macrophage interactions and stimulates MMPs (matrix metalloproteinases) and vascular endothelial growth factor (VEGF).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy.
Wu B, et al.
Cell Death and Differentiation, 8(7), e2925-e2925 (2017)
CD147 overexpression may serve as a promising diagnostic and prognostic marker for gastric cancer: evidence from original research and literature.
Hu C, et al.
Oncotarget, 8(19), 30888?30899-30888?30899 (2017)
Simvastatin attenuated rat thoracic aorta remodeling by decreasing ROCK2?mediated CyPA secretion and CD147-ERK1/2-cyclin pathway.
Tang FC, et al.
Molecular Medicine Reports, 16(6), 8123-8129 (2017)
CD147-induced cell proliferation is associated with Smad4 signal inhibition.
Qin H, et al.
Experimental Cell Research, 358(2), 279-289 (2017)
BGMUT: NCBI dbRBC database of allelic variations of genes encoding antigens of blood group systems.
Patnaik SK, et al.
Nucleic Acids Research, 40(D1), D1023-D1029 (2011)

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