SAB4502981
Anti-Claudin 5, C-Terminal antibody produced in rabbit
affinity isolated antibody
Synonym(s):
CLD5, CLDN5, TMDVCF, Transmembrane protein deleted in VCFS
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 23 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CLDN5(7122)
General description
Anti-Claudin 5 Antibody detects endogenous levels of total Claudin 5 protein.
The CLDN5 (claudins) gene is mapped to human chromosome 22q11.21 and codes for a transmembrane protein, which is a component of tight junction. The protein is a part of blood-brain barrier. The encoded protein is 303 - 218 amino acids long.
Immunogen
The antiserum was produced against synthesized peptide derived from human Claudin 5.
Immunogen Range: 169-218
Immunogen Range: 169-218
Application
Anti-Claudin 5, C-Terminal antibody produced in rabbit has been used for intravascular perfusion labelling of vascular endothelial- cadherin and Immunofluorescence.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunocytochemistry (1 paper)
Biochem/physiol Actions
The CLDN5 (claudins) gene encodes a component of tight junction and serves as a selective barrier for solutes and water. Upregulation of CLDN5 was observed in migraine. The expression of CLDN5 is reduced in lung squamous carcinoma. CLDN5 is known to increase p21 and decrease cyclin D1, leading to the retardation of cell cycle G1 to S transition. Cldn5 maintains homeostasis of the central nervous system, being a part of blood-brain barrier.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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B-acute lymphoblastic leukemia and cystinuria in a patient with duplication 22q11.21 detected by chromosomal microarray analysis.
Chang VY
Pediatric Blood & Cancer, 56(3), 470-473 (2011)
Correlation between the radial peripapillary capillaries and the retinal nerve fibre layer in the normal human retina.
Yu PK
Experimental Eye Research, 129, 83-92 (2014)
Serum levels of endocan, claudin-5 and cytokines in migraine.
Yucel M
European Review for Medical and Pharmacological Sciences, 20(5), 930-936 (2016)
Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform.
Cornely RM
Annals of the New York Academy of Sciences, 1397(1), 119-129 (2017)
Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-?1 in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosis.
Togami K
Journal of Pharmacological and Toxicological Methods, 86, 19-27 (2017)
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