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SAB4503081

Sigma-Aldrich

Anti-Vimentin antibody produced in rabbit

affinity isolated antibody

Synonym(s):

VIME, vimentin

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 53 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI accession no.

P08670

UniProt accession no.

P08670

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... VIM(7431)

General description

Anti-Vimentin Antibody detects endogenous levels of total Vimentin protein.
The VIM (vimentin) gene codes for an intermediate filament protein, that is expressed throughout mesenchymal cells. VIM gene is mapped to human chromosome 10p13.

Immunogen

The antiserum was produced against synthesized peptide derived from human Vimentin.

Immunogen Range: 56-105

Biochem/physiol Actions

Vimentin is known to promote epithelial to mesenchymal transition and contributes to metastasis in cancer such as ovarian cancer. Vimentin preserves cellular structure and tissue integrity. Vimentin is also known to bring about TNF-α (tumor necrosis factor-α) induced cell apoptosis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The ubiquitin ligase TRIM56 inhibits ovarian cancer progression by targeting vimentin.
Zhao L, et al.
Journal of Cellular Physiology (2018)
Toshiaki Miyazaki et al.
Oncogenesis, 7(1), 7-7 (2018-01-25)
The antitumor immune response is a critical defense system that eliminates malignant cells. The failure of the system results in immune escape and proceeds to tumor growth. We have previously showed that estrogen receptor-binding fragment-associated antigen 9 (EBAG9) is a
Tumor HLA?DR expression linked to early intrahepatic recurrence of hepatocellular carcinoma
Matoba K, et al.
International Journal of Cancer. Journal International Du Cancer, 115(2), 231-240 (2005)
Lifeng Yang et al.
Toxicology, 389, 74-84 (2017-07-27)
Both RhoA/ROCK and Raf-1/CK2 pathway play essential roles in cell proliferation, apoptosis, differentiation, and multiple other common cellular functions. We previously reported that vimentin is responsible for TNF-α-induced cell apoptosis. Herein, we investigated the regulation of RhoA/ROCK and Raf-1/CK2 signaling
Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial?mesenchymal transition-related proteins.
Liu P F, et al.
PLoS ONE, 12(6), e0178581-e0178581 (2017)
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