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SAB4503968

Sigma-Aldrich

Anti-phospho-PECAM-1 (pTyr713) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 82 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

P16284

UniProt accession no.

P16284

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr713)

Gene Information

human ... PECAM1(5175)

General description

The platelet and endothelial cell adhesion molecule 1 (PECAM1) is also termed as cluster of differentiation 31 (CD31). It belongs to the immunoglobulin (Ig) superfamily. This gene codes for a 130kDa protein and is located on human chromosome 17. PECAM1 is expressed on the surface of circulating platelets, monocytes, neutrophils and selected T-cell subsets.

Immunogen

The antiserum was produced against synthesized peptide derived from human PECAM-1 around the phosphorylation site of Tyr713.

Immunogen Range: 686-735

Biochem/physiol Actions

The platelet and endothelial cell adhesion molecule 1 (PECAM1) participates in leukocyte-endothelial interaction.This protein has a major role in the adhesion cascade leading to leukocyte extravasation during the inflammatory process. PECAM1 also plays a role during the development of T cell.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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CD31, a Valuable Marker to Identify Early and Late Stages of T Cell Differentiation in the Human Thymus
Douaisi M, et al.
Journal of Immunology, 198(6), 2310-2319 (2017)
Serum sPECAM-1 and sVCAM-1 levels are associated with conversion to multiple sclerosis in patients with optic neuritis
Kalinowska-Lyszczarz A, et al.
Journal of Neuroimmunology, 300, 11-14 (2016)
The biology of PECAM-1
P J Newman
The Journal of Clinical Investigation, 99 (1997)

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