SAB4700267
Monoclonal Anti-CD64 antibody produced in mouse
clone 10.1, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-FCGR1, Anti-FcγRI
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
10.1, monoclonal
form
buffered aqueous solution
species reactivity
human, nonhuman primates
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG1
NCBI accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... FCGR1(2209)
Related Categories
General description
The mouse monoclonal antibody 10.1 recognizes alpha subunit of CD64/FcgammaRI, a 72 kDa single chain type I glycoprotein, that is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes.
Immunogen
Rheumatoid synovial fluid cells and fibronectin purified human monocytes
Application
Cluster of differentiation 64 (CD64) has been implicated in various immunological processes such as phagocytosis, the clearance of immune complexes and the secretion of immunological mediators. In addition, it also facilitates antibody-dependent cellular cytotoxicity, the modulation of B-cell differentiation and transcytosis of IgG across the epithelial layer. Neutrophil CD64 serves as a potent diagnostic marker for bacterial infection and neonatal sepsis.
Biochem/physiol Actions
The cluster of differentiation 64 (CD64), also known as Fc fragment of IgG receptor Ia (FCGR1A), gene is mapped to human chromosome lq21.2--q21.3. The gene codes for a 72 kDa glycoprotein that is constitutively expressed on human monocytes and macrophages.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Neutrophil CD64 as a diagnostic marker for neonatal sepsis: Meta-analysis.
Dai J, et al.
Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University, 327-332 (2017)
Neutrophil CD64 expression as a longitudinal biomarker for severe disease and acute infection in critically ill patients.
Jong E, et al.
International Journal of Laboratory Hematology, 38(5), 576-584 (2016)
Human high-affinity Fc?RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization
Takai S, et al.
Human Genetics, 93(1), 13-15 (1994)
Sridevi Devaraj et al.
American journal of physiology. Heart and circulatory physiology, 291(3), H1170-H1176 (2006-04-11)
Monocyte-endothelial cell adhesion is a key early event in atherogenesis. C-reactive protein (CRP), a cardiovascular risk marker, is known to stimulate ICAM and VCAM in human aortic endothelial cells (HAEC) and induces monocyte-endothelial cell adhesion. In this study, we examined
Marcia Nascimento et al.
PLoS pathogens, 10(8), e1004282-e1004282 (2014-08-22)
Accumulation of M2 macrophages in the liver, within the context of a strong Th2 response, is a hallmark of infection with the parasitic helminth, Schistosoma mansoni, but the origin of these cells is unclear. To explore this, we examined the
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