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SAB5200024

Sigma-Aldrich

Monoclonal Anti-HCN1 antibody produced in mouse

clone S70-28, 1 mg/mL, purified immunoglobulin

Synonym(s):

Anti-BCNg1, Anti-HAC2, Anti-HCN1, S70-28, Anti-potassium/sodium hyperpolarization activted cycli nucleotide gated channel 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

S70-28, monoclonal

form

buffered aqueous glycerol solution

mol wt

antigen predicted mol wt 100 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NP_445827.1

UniProt accession no.

O60741

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... HCN1(84390)

Related Categories

Specificity

Detects ~100 kDa. No cross-reactivity against HCN2

Immunogen

Fusion protein amino acids 778-910 (C terminus) of rat HCN1, Accession Number Q9JKBO

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chang-jun Li et al.
Molecular neurobiology, 50(2), 704-720 (2014-05-20)
Hyperpolarization-activated cyclic-nucleotide-gated cation nonselective (HCN) channels are involved in the pathology of nervous system diseases. HCN channels and γ-aminobutyric acid (GABA) receptors can mutually co-regulate the function of neurons in many brain areas. However, little is known about the co-regulation
Hongxia Li et al.
Clinical and experimental pharmacology & physiology, 41(9), 698-707 (2014-05-28)
The pacemaker current If conducted by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels plays a critical role in the regulation of cardiac automaticity, with If density increased in hypertrophied ventricular myocytes. Amiodarone, a highly effective anti-arrhythmic agent, blocks human HCN currents and

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