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SAB5200898

Sigma-Aldrich

Monoclonal Anti-Glun2A/Nr2A - Apc antibody produced in mouse

clone S327-95, purified immunoglobulin

Synonym(s):

Anti-GRIN2A, Anti-HNR2A, Anti-NMDA 2A

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

Allophycocyanin conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

S327-95, monoclonal

form

buffered aqueous solution

mol wt

antigen predicted mol wt 170 kDa

species reactivity

human, rat, mouse

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG2a

NCBI accession no.

NP_036705.3

UniProt accession no.

Q12879

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Grin2a(24409)

Related Categories

General description

The GRIN2A (glutamate ionotropic receptor NMDA (N-methyl-D-aspartate) type subunit 2A) gene is mapped to human chromosome 16p13.2. It codes for a transmembrane ligand-gated ion channel called N-methyl-D-aspartate glutamate receptor α2 subunit.

Immunogen

Fusion protein amino acids 75-325 (extracellular N-terminus) of rat GluN2A/NR2A

Biochem/physiol Actions

The GRIN2A (glutamate ionotropic receptor NMDA (N-methyl-D-aspartate) type subunit 2A) gene is associated with focal epilepsy and impaired speech. NMDA glutamate receptor α2 subunit is involved in neuron development, maintains synaptic plasticity and is associated with memory. GRIN2A is related to schizophrenia and Alzheimer′s disease. Mutations in GRIN2A gene upregulates NMDA action and might lead to melanoma tumors. NMDA participates in apoptosis and proliferation of cancer cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency-molecular profiling and functional rescue
Addis L, et al.
Scientific Reports, 7(1), 66-66 (2017)
Selected GRIN2A mutations in melanoma cause oncogenic effects that can be modulated by extracellular glutamate
Dmello SAN, et al.
Cell Calcium, 60(6), 384-395 (2016)
2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor
Gorska PM, et al.
Journal of Cellular Physiology, 232(11), 3030-3049 (2017)
Epilepsy in patients with GRIN2A alterations: genetics, neurodevelopment, epileptic phenotype and response to anticonvulsive drugs
von Stupnagel C, et al.
European Journal of Paediatric Neurology, 21(3), 530-541 (2017)
GRIN2A mutations in epilepsy-aphasia spectrum disorders
Yang X, et al.
Brain & Development, 40(3), 205-210 (2018)

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