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SAB5300394

Sigma-Aldrich

Monoclonal Anti-PTK2B antibody produced in mouse

clone 5E2D5, ascites fluid

Synonym(s):

CAKB, FAK2, FRNK, PKB, PTK

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

5E2D5, monoclonal

mol wt

115.8 kDa

species reactivity

human

technique(s)

direct ELISA: 1:10,000
immunohistochemistry: 1:200-1:1,000
western blot: 1:500-1:2,000

isotype

IgG2a

NCBI accession no.

NM_173174

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PYK2(2185)

General description

Protein tyrosine kinase 2 β (PTK2B) is a member of the focal adhesion kinase family which is expressed in the brain. The gene encoding it is localized on human chromosome 8.

Immunogen

Purified recombinant fragment of PYK2 (aa815-997) expressed in E.coli.
Mouse monoclonal antibody raised against PYK2

Biochem/physiol Actions

Protein tyrosine kinase 2 β (PTK2B) takes part in the β2-mediated signaling pathway and activates mitogen activated protein kinase pathway. The protein has been shown to be upregulated in many tumors. PTK2B also has a role in cell proliferation and migration. It regulates ion channels which are induced by calcium.

Physical form

Ascitic fluid containing 0.03% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Maria Steblyanko et al.
The Journal of biological chemistry, 290(19), 11833-11842 (2015-03-18)
Integrin engagement on lymphocytes initiates "outside-in" signaling that is required for cytoskeleton remodeling and the formation of the synaptic interface. However, the mechanism by which the "outside-in" signal contributes to receptor-mediated intracellular signaling that regulates the kinetics of granule delivery
Heval M Ozgen et al.
Journal of autism and developmental disorders, 39(2), 322-329 (2008-08-13)
Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders with a strong genetic etiology. Cytogenetic abnormalities have been detected in 5-10% of the patients with autism. In this study, we present the clinical, cytogenetic and array-comparative genomic hybridization (array-CGH)
Elinor Y Gottschalk et al.
Journal of virology, 89(17), 9103-9114 (2015-06-26)
The infectious process of human papillomaviruses (HPVs) has been studied considerably, and many cellular components required for viral entry and trafficking continue to be revealed. In this study, we investigated the role of the nonreceptor tyrosine kinase Pyk2 during HPV16
Yu Zhang et al.
Blood, 124(17), 2675-2686 (2014-09-14)
Proline-rich tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family that has been recently linked to tumor development. However, its role in modulating multiple myeloma (MM) biology and disease progression remains unexplored. We first demonstrated that

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