SAB5500151
Anti-Neutrophil Elastase antibody, Rabbit monoclonal
clone SP203, recombinant, expressed in proprietary host, affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
SP203, monoclonal
species reactivity
human (tested)
technique(s)
immunohistochemistry: 1:100
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... ELANE(1991)
General description
Neutrophil elastase (NE) is a monomeric protein, encoded by the gene mapped to human chromosome 19p13.3. The protein has a molecular mass of 25 kDa and is mainly present in the neutrophil granules (located in the neutrophil cytoplasm).
Neutrophil elastase is a serine proteinase synthesized by promyelocytes and promonocytes. It is secreted by neutrophils to degrade extracellular matrix, and to destroy bacteria. It is used as a marker for myeloid leukemia cells.
Immunogen
Synthetic peptide from human neutrophil elastase protein.
Biochem/physiol Actions
Neutrophil elastase (NE) is a key driver of inflammation in many cardiopulmonary and systemic inflammatory and autoimmune conditions. The encoded protein catalyzes the cleavage of tyrosyl-tRNA synthetase to produce cytokine domains that stimulates neutrophil chemotaxis. In addition, NE also facilitates the secretion of the neutrophil chemoattractant, interleukin-8 from endothelial cells.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Franz von Nussbaum et al.
ChemMedChem, 11(2), 199-206 (2015-09-04)
Human neutrophil elastase (HNE) is a key driver of inflammation in many cardiopulmonary and systemic inflammatory and autoimmune conditions. Overshooting high HNE activity is the consequence of a disrupted protease-antiprotease balance. Accordingly, there has been an intensive search for potent
Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis
Horwitz M, et al.
Nature Genetics, 23(4), 433-433 (1999)
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