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SAB5600004

Sigma-Aldrich

Anti-Mouse IgG2c antibody, Rabbit monoclonal

recombinant, expressed in HEK 293 cells, clone RM223, purified immunoglobulin

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46

recombinant

expressed in HEK 293 cells

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

RM223, monoclonal
recombinant monoclonal

form

buffered aqueous glycerol solution

species reactivity

mouse

concentration

~1 mg/mL

technique(s)

ELISA: 0.01 μg/mL
immunoblotting: 0.5-2 μg/mL (non-reduced only)
immunocytochemistry: 0.5-2 μg/mL
immunohistochemistry: 0.5-2 μg/mL

isotype

IgG

NCBI accession no.

404711

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Related Categories

General description

IgG2c codes for Igh-1b. In mice, IgG2a and IgG2c are arranged in tandem on identical chromosome as two visible loci.

Specificity

This antibody reacts to the Fc region of mouse IgG2c. No cross reactivity with mouse IgG1, IgG2a, IgG2b, IgG3, IgM, IgA, IgE, human IgG, or rat IgG.

Immunogen

Purified mouse IgG2c whole molecule

Biochem/physiol Actions

Mouse IgG2c generate several unique non-bonded interactions between the BC, DE and FG loops than mIgG2b. It connects to FcγRIV (Fc γ receptor IV) with a high affinity in the complex-type glycoform. In mice, IgG2c has unique immune profiles like, response, immune-decoration, because of their difference in protein sequence.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mouse IgG2c Fc loop residues promote greater receptor-binding affinity than mouse IgG2b or human IgG1.
Daniel JF, et al.
PLoS ONE, 13(2), e0192123-e0192123 (2018)
Possible allelic structure of IgG2a and IgG2c in mice.
Zhang Z, et al.
Molecular Immunology, 50(3), 169-171 (2012)

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