SAB5702238
Anti-PD-L1/CD274 Antibody, clone 8F1V6, Rabbit Monoclonal
Synonym(s):
B7-H,B7H1,PDL1,PD-L1,PDCD1L1,PDCD1LG1,CD274
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.46
Recommended Products
biological source
rabbit
Quality Level
material
colorless
clone
8F1V6, monoclonal
form
liquid
species reactivity
human
concentration
0.65 mg/mL
technique(s)
flow cytometry: 1:50 - 1:200
color
colorless
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PD-L1(29126)
General description
Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and non-hematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1-PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PD-L1 has become an important biomarker and immunotherapy target for many types of malignancies.
Immunogen
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Recombinant protein of human PD-L1/CD274.
Application
ELISA, WB, FC, Inhibition
wgk_germany
WGK 1
Certificates of Analysis (COA)
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