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SML0307

Sigma-Aldrich

Pleconaril

≥98% (HPLC)

Synonym(s):

3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole, VP 63843, Win 63843

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About This Item

Empirical Formula (Hill Notation):
C18H18F3N3O3
CAS Number:
153168-05-9
Molecular Weight:
381.35
MDL number:
MFCD00923611
UNSPSC Code:
12352200
PubChem Substance ID:
329825312
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥10 mg/mL (warmed)

storage temp.

room temp

SMILES string

Cc1cc(CCCOc2c(C)cc(cc2C)-c3noc(n3)C(F)(F)F)on1

InChI

1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3

InChI key

KQOXLKOJHVFTRN-UHFFFAOYSA-N

General description

Pleconaril is a drug, that has antiviral activity.

Application

Pleconaril has been used as a control or reference compound to assess the antiviral activities of the benzothiophene and other heteroaromatic derivatives against hRV-B14, hRV-A21 and hRV-A71.

Biochem/physiol Actions

Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors.
Pleconaril is an orally bioavailable, broad-spectrum antipicorna-viral agent that binds to hydrophobic pocket in VP1 major capsid protein. Also, pleconaril delays the onset of diabetes in experimental animals infected with Ljungan virus (LV).

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H413

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Viral infections
Textbook of Clinical Neurology (Third Edition), 919-942 (2007)
A novel series of highly potent small molecule inhibitors of rhinovirus replication
Kim J, et al.
Journal of Medicinal Chemistry, 60(13), 5472-5492 (2017)
Microscopic determination of drug solubility in plasma and calculation of injection rates with a plasma circulatory model to prevent precipitation on intravenous injection.
G A Portmann et al.
Journal of pharmaceutical and biomedical analysis, 13(9), 1189-1193 (1995-08-01)
Chronic meningoencephalitis caused by Echo virus 6 in a patient with common variable immunodeficiency
Radanovic I, et al.
Wiener Klinische Wochenschrift, 130(1-2), 70-72 (2018)
Chunlong Ma et al.
ACS infectious diseases, 5(11), 1952-1962 (2019-09-19)
Enterovirus D68 (EV-D68) is a respiratory viral pathogen that primarily infects children under the age of 8. Although EV-D68 infection typically leads to moderate to severe respiratory illnesses, recent years have seen increasing cases of EV-D68 triggered neurological complications such
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