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SML0314

Sigma-Aldrich

CGP77675

≥98% (HPLC)

Synonym(s):

1-(2-{4-[4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl}ethyl)piperidin-4-ol, 1-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol, CGP 77675, CGP-77675

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About This Item

Empirical Formula (Hill Notation):
C26H29N5O2
CAS Number:
234772-64-6
Molecular Weight:
443.54
MDL number:
MFCD20039929
UNSPSC Code:
12352200
PubChem Substance ID:
329825319
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

COc1cccc(c1)-c2cn(-c3ccc(CCN4CCC(O)CC4)cc3)c5ncnc(N)c25

InChI

1S/C26H29N5O2/c1-33-22-4-2-3-19(15-22)23-16-31(26-24(23)25(27)28-17-29-26)20-7-5-18(6-8-20)9-12-30-13-10-21(32)11-14-30/h2-8,15-17,21,32H,9-14H2,1H3,(H2,27,28,29)

InChI key

WUPXZZWTHIZICK-UHFFFAOYSA-N

General description

CGP77675 belongs to the pyrrolopyrimidine class of inhibitors.

Application

CGP77675 has been used in the generation of mouse expanded potential stem cells.

Biochem/physiol Actions

CGP77675 is a potent Src kinase inhibitor. CGP77675 is selective toward other protein kinases including Cdc2 (>500-fold), epidermal growth factor (EGF) receptor (7.5-fold), vascular endothelial growth factor receptor (>50-fold), and for v-Abl (15-fold) and focal adhesion kinase (Fak) (>25-fold).
CGP77675 prevents hypercalcemia stimulated by interleukin 1β. It is known to offer protection against bone loss in ovariectomized mice. CGP77675 is known for its use in cancer treatment.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Ingun Heiene Tveteraas et al.
Journal of experimental & clinical cancer research : CR, 31, 72-72 (2012-09-13)
It is important to understand the mechanisms by which the cells integrate signals from different receptors. Several lines of evidence implicate epidermal growth factor (EGF) receptor (EGFR) in the pathophysiology of hepatocarcinomas. Data also suggest a role of prostaglandins in
Establishment of mouse expanded potential stem cells
Yang J, et al.
Nature, 550(7676), 393-393 (2017)
Targeted Interference with Signal Transduction Events, 177-177 (2007)
Osteoporosis, 798-798 (2001)
Dandan Liu et al.
Life sciences, 259, 118273-118273 (2020-08-18)
To explore the mechanisms of erythropoietin (EPO)'s protection on inner blood-retinal barrier (iBRB) in experimental diabetic retinopathy. Male SD rats were rendered diabetic with streptozotocin, followed by intravitreal injection of EPO. The permeability of iBRB was examined with fluorescein isothiocyanate
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