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SML0413

Sigma-Aldrich

FQI1

≥98% (HPLC)

Synonym(s):

8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one

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About This Item

Empirical Formula (Hill Notation):
C18H17NO4
CAS Number:
599151-35-6
Molecular Weight:
311.33
MDL number:
MFCD03632583
UNSPSC Code:
12352200
PubChem Substance ID:
329825408
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

O=C1CC(C2=CC=CC=C2OCC)C3=CC4=C(OCO4)C=C3N1

InChI

1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20)

InChI key

YKSYGLXHLSPWLB-UHFFFAOYSA-N

Biochem/physiol Actions

FQI1 inhibits the DNA-binding activity of LSF, a ubiquitous transcription factor that is up regulated in many hepatocellular carcinomas (HCC). FQI1 inhibits LSF-dependent luciferase reporter expression, blocks proliferation in cancer cell lines, and induces apoptosis in liver cancer cells but is not toxic to primary hepatocytes. FQI1 also inhibits tumor growth in a mouse HCC xenograft model.

wgk_germany

WGK 3

Certificates of Analysis (COA)

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Jennifer L S Willoughby et al.
BMC cancer, 20(1), 552-552 (2020-06-17)
The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular carcinoma and colorectal cancer. The limited treatment outcomes for

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