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SML0448

Sigma-Aldrich

URB937

≥95% (HPLC)

Synonym(s):

Cyclohexylcarbamic acid 3′–carbamoyl–6–hydroxybiphenyl–3–yl ester

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About This Item

Empirical Formula (Hill Notation):
C20H22N2O4
CAS Number:
1357160-72-5
Molecular Weight:
354.40
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥95% (HPLC)

form

powder (1:1 ratio of product to ethanol)

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

InChI

1S/C20H22N2O4/c21-19(24)14-6-4-5-13(11-14)17-12-16(9-10-18(17)23)26-20(25)22-15-7-2-1-3-8-15/h4-6,9-12,15,23H,1-3,7-8H2,(H2,21,24)(H,22,25)

InChI key

CMEQHOXCIGFZNJ-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

URB937 is a fatty acid amide hydrolase (FAAH) inhibitor that is actively excluded from the CNS by the membrane transporter ABCG2. The ED50 for inhibition of FAAH activity in the brain is 200 times higher than inhibition of renal FAAH activity. In vivo administration of URB937 elevates anandamide levels in peripheral tissues, and attenuates acetic acid-induced writhing, hyperalgesia in a sciatic nerve ligation model, and pain and edema in carrageenan injected paws.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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