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SML0603

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Lixivaptan

≥96% (HPLC)

Synonym(s):

N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide, VPA 985, WAY-VPA 985

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About This Item

Empirical Formula (Hill Notation):
C27H21ClFN3O2
CAS Number:
168079-32-1
Molecular Weight:
473.93
UNSPSC Code:
51111800
NACRES:
NA.77

description

4% w/w in ethyl acetate

Quality Level

100

assay

≥96% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

InChI

1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33)

InChI key

PPHTXRNHTVLQED-UHFFFAOYSA-N

Biochem/physiol Actions

Arginine vasopressin (AVP) plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). Lixivaptan is an AVP V2-receptor selective antagonist that increases water excretion and normalizes serum sodium levels. Lixivaptan has been in clinical trials for hyponatremia associated with heart failure.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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