SML0765
SR1555
≥98% (HPLC)
Synonym(s):
1,1,1,3,3,3-Hexafluoro-2-(4′-((1-(acetyl) piperazine) methyl)-[1,1′-biphenyl]-4-yl)propan-2-ol
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About This Item
Empirical Formula (Hill Notation):
C22H22F6N2O2
CAS Number:
Molecular Weight:
460.41
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
SR1555 is a selective RORγ inverse agonist that inhibits the development and function of TH17 cells, a subset of T cells that have been implicated in the pathology of several autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. SR1555 also increases the frequency of T regulatory cells, an effect not seen with previously described RORγ ligands.
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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M-H Haddadi et al.
Clinical and experimental immunology, 201(2), 205-221 (2020-05-14)
Regulatory T (Treg ) cell therapy is a promising approach for immune tolerance induction in autoimmunity conditions and cell/organ transplantations. Insufficient isolation yields and impurity during downstream processes and Treg instability after adoptive transfer in inflammatory conditions are major limitations
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