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SML0797

Sigma-Aldrich

Flibanserin

≥98% (HPLC)

Synonym(s):

1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one, BIMT 17, BIMT 17BS

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About This Item

Empirical Formula (Hill Notation):
C20H21F3N4O
CAS Number:
167933-07-5
Molecular Weight:
390.40
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C20H21F3N4O/c21-20(22,23)15-5-7-16(8-6-15)26-12-9-25(10-13-26)11-14-27-18-4-2-1-3-17(18)24-19(27)28/h1-8H,9-14H2,(H,24,28)

InChI key

CCIZQGRSEAHATK-UHFFFAOYSA-N

Biochem/physiol Actions

Flibanserin is a 5-HT1A receptor agonist and 5-HT2A receptor antagonist. Flibanserin has high affinity for human 5-HT1A receptors (Ki = 1 nm) and lower affinity for 5-HT2A (Ki = 49 nm) and D4 (Ki = 4–24 nm) receptors, and negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin was investigated as a novel, non-hormonal treatment for pre-menopausal women with Hypoactive Sexual Desire Disorder (HSDD). Flibanserin. Recently, Flibanserin was found to reduce L-DOPA-induced dyskinesia in a model of Parkinson′s Disease.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Min-Yong Low et al.
Journal of pharmaceutical and biomedical analysis, 57, 104-108 (2011-10-01)
A health supplement used for female sexual performance enhancement was sent to Health Sciences Authority of Singapore for testing. An unknown compound was detected and isolated from the health supplement and its structure was elucidated using LC-DAD, LC-FTMS, NMR and
[When women complain about lacking libido. The problem with the desire].
Katharina Arnheim
MMW Fortschritte der Medizin, 152(34-35), 12-13 (2010-10-07)
Evan R Goldfischer et al.
The journal of sexual medicine, 8(11), 3160-3172 (2011-09-22)
Flibanserin is a 5-HT(1A) agonist/5-HT(2A) antagonist that has been shown to increase sexual desire and reduce distress in premenopausal women with Hypoactive Sexual Desire Disorder (HSDD). To assess the efficacy and safety of flibanserin over 24 weeks of double-blind treatment
Resurgence of interest in sexual dysfunction?
Mike G Wyllie
BJU international, 109(11), E36-E37 (2012-05-09)
Iñaki F Trocóniz et al.
Pharmaceutical research, 29(6), 1518-1529 (2012-01-06)
Flibanserin is being developed for treating hypoactive sexual desire disorder in women; the main side effect is sedation. The analysis objective was to relate flibanserin plasma concentrations with acute sedative effects using a population pharmacokinetic/pharmacodynamic (PK/PD) model. The population model
View All Related Papers

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