SML0884
bpV(HOpic)
≥90% V basis
Synonym(s):
Bisperoxovanadium(HOpic), Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V), K2[VO(O2)2C6H4NO3]
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About This Item
Empirical Formula (Hill Notation):
K2VOO2O2C6H4NO3
CAS Number:
Molecular Weight:
347.24
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥90% V basis
form
powder
storage condition
desiccated
protect from light
color
faintly yellow to dark yellow
solubility
H2O: 20 mg/mL, clear
storage temp.
−20°C
Application
bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway.
Biochem/physiol Actions
bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTPβ and 25.3 μM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury.
Other Notes
Soluble in DMSO or water. NOTE: The product is not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Directed migration of cancer cells guided by the graded texture of the underlying matrix.
Park J, et al.
Nature Materials, 15(7), 792-792 (2016)
Thomas Theis et al.
Molecular neurobiology, 55(10), 8203-8215 (2018-03-10)
Glycosylation fine-tunes signal transduction of adhesion molecules during neural development and supports synaptic plasticity and repair after injury in the adult nervous system. One abundantly expressed neural glycan is LewisX (LeX). Although it is known that its expression starts at
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