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SML1515

Sigma-Aldrich

Anle138b

≥98% (HPLC)

Synonym(s):

3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole, 5-(1,3-Benzodioxol-5-yl)-3-(3-bromophenyl)-1H-pyrazole, Anle 138b, CID 44608289

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About This Item

Empirical Formula (Hill Notation):
C16H11BrN2O2
CAS Number:
882697-00-9
Molecular Weight:
343.17
UNSPSC Code:
12352200
PubChem Substance ID:
329825932
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

BrC1=CC(C2=CC(C3=CC(OCO4)=C4C=C3)=NN2)=CC=C1

InChI

1S/C16H11BrN2O2/c17-12-3-1-2-10(6-12)13-8-14(19-18-13)11-4-5-15-16(7-11)21-9-20-15/h1-8H,9H2,(H,18,19)

InChI key

RCQIIBJSUWYYFU-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Anle138b is a fluorescent inhibitor of α-synuclein and prion-protein (PrPSc) aggregation that reduces the progression of prion and Parkinson′s disease in animal models. Anle138b extends the survival of mice infected with prions. Anle138b strongly inhibits BSE-derived and human prions. The fluorescence strongly increases upon binding with α-synuclein fibrils. Apparently, Anie138b binds to hydrophobic pockets in the fibrils.
Anle138b, an oligomer modulator, inhibits neuronal degeneration. It rescues neurons from the aggregation effects of α-synuclein.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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