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SML1530

Sigma-Aldrich

SB-334867

≥98% (HPLC)

Synonym(s):

N-(2-Methyl-6-benzoxazolyl)-N′-1,5-naphthyridin-4-yl-urea, SB-334867, SB-334867A, SB334867

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About This Item

Empirical Formula (Hill Notation):
C17H13N5O2
CAS Number:
792173-99-0
Molecular Weight:
319.32
MDL number:
MFCD06411602
UNSPSC Code:
12352200
PubChem Substance ID:
329825947

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

O=C(NC1=CC=C(N=C(C)O2)C2=C1)NC3=CC=NC4=C3N=CC=C4

InChI

1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23)

InChI key

AKMNUCBQGHFICM-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Lateral hypothalamic orexin neuron activation leads to the development of morphine conditioned place preference, which is preferably blocked by SB-334867.
SB-334867 is a non-peptide selective antagonist of the orexin OX1 receptor. SB-334867 blocks orexin-A induced calcium response with a pKb of 7.23. SB-334867 blocks increases in heart rate and body temperature induced by administratin of methamphetamine, and can inhibit the development of tolerance to the analgesic properties of morphine in rodent models. SB-334867 also shows anxiolytic and sedative effects.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315

Hazard Classifications

Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high?fat food self?administration and reinstatement of food seeking in rats.
Nair S G, et al.
British Journal of Pharmacology, 154(2), 406-416 (2008)

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