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SML1547

Sigma-Aldrich

RN-9893

≥98% (HPLC)

Synonym(s):

N-(4-(4-Isopropylpiperazin-1-ylsulfonyl)phenyl)-2-nitro-4-(trifluoromethyl)benzamide

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About This Item

Empirical Formula (Hill Notation):
C21H23F3N4O5S
CAS Number:
1803003-68-0
Molecular Weight:
500.49
UNSPSC Code:
12352200
PubChem Substance ID:
329825956

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NC1=CC=C(S(=O)(N2CCN(C(C)C)CC2)=O)C=C1)C3=CC=C(C(F)(F)F)C=C3[N+]([O-])=O

InChI

1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)

InChI key

KORKKQLDGMHNKO-UHFFFAOYSA-N

General description

RN-9893 is a small, orally bioavailable antagonist of TRPV4 (transient receptor potential subfamily V4. It is a tri-substituted benzamide compound.

Biochem/physiol Actions

RN-9893 is a potent and selective antagonist of the Transient Receptor Potential ion channel TRPV4. RN-9893 has IC50 values of 420 nM, 660 nM, and 320 nM for human, rat and mouse TRPV4 receptors, respectively. RN-9893 shows excellent selectivity over related TRP receptors with no inhibition of TRPV1 at a concentration of 10 μM, an IC50 >30 μM against TRPV3, an IC50 of approximately 30 μM against TRPM8, and also good selectivity using 54 binding assays against common biological targets.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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TRPV4 agonists and antagonists.
Vincent F and Duncton MA
Current Topics in Medicinal Chemistry, 11(17), 2216-2226 (2011)
Identification of orally-bioavailable antagonists of the TRPV4 ion-channel.
Wei ZL et al
BioTechnology: An Indian Journal, 25(18), 4011-4015 (2015)

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